Eicosanoids, SPM & Vascular Pharmacology

Human vascular tissue research
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Prostanoid receptors
in human pulmonary vessels

Prostanoid receptors
in human vessels

Cholinergic control
in human pulmonary vessels

Leukotriene receptors
in human pulmonary vessels

Laboratory & Links

Publications

Prostanoid receptors in the human pulmonary vessels

Prostanoid Receptor	Effect	pD₂value of selective agonists	*Go to references*
*Human pulmonary artery*
TP	contraction	U46619: 7.96	Maddox et al., 1985 (TP) Norel et al., 1990; 1991 (TP, IP) Quian et al., 1994 (TP, EP3) Haye-legrand et al., 1987 (IP) Walch et al., 1999 (IP) Benyahia et al., 2013 (IP)
EP3	contraction	sulprostone : 8.26
IP	relaxation	cicaprost: 7.48-8.06
		iloprost: 7.84-7.94
		treprostinil: 6.73
		PGI2: 6.68
*Human pulmonary vein*
TP	contraction	U46619: 8.56	Walch et al., 1999 (IP, DP) Benyahia et al., 2013 (IP) Walch et al., 2001 (TP, EP1) Foudi et al., 2008 (EP4)
EP1	contraction	17-phenyl-PGE2 : 8.64sulprostone: 7.87
IP	relaxation	iloprost: 7.96-8.25 cicaprost: 8.11 treprostinil: 7.49
DP	relaxation	BW245C: 7.31 PGD2: 6.89 treprostinil: 7.49
EP4	relaxation	PGE2: 8.10 misoprostol : 6.24

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Eicosanoids, SPM & Vascular Pharmacology

Prostanoid Receptor

Effect

pD2 value of selective agonists

Go to references

pD₂value of selective agonists