Eicosanoids & Vascular Pharmacology

Human vascular tissue research
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Last update: 14/06/18


Prostanoid receptors in the human pulmonary vessels

Prostanoid Receptor  

Effect 

pD2 value of selective agonists 

Go to references  

Human pulmonary artery
TP contraction U46619: 7.96
Maddox et al., 1985 (TP)
Norel et al., 1990; 1991 (TP, IP)
Quian et al., 1994 (TP, EP3)
Haye-legrand et al., 1987 (IP)
Walch et al., 1999 (IP) Benyahia et al., 2013 (IP)
EP3 contraction sulprostone : 8.26
IP relaxation cicaprost: 7.48-8.06
    iloprost: 7.84-7.94
    treprostinil: 6.73
    PGI2: 6.68
Human pulmonary vein
TP   contraction U46619: 8.56

Walch et al., 1999 (IP, DP)
Benyahia et al., 2013 (IP)
Walch et al., 2001 (TP, EP1)
Foudi et al., 2008 (EP4)

EP1   contraction

17-phenyl-PGE2 : 8.64sulprostone: 7.87

IP relaxation

iloprost: 7.96-8.25
cicaprost: 8.11
treprostinil: 7.49

DP relaxation

BW245C: 7.31
PGD2: 6.89
treprostinil: 7.49

EP4 relaxation

PGE2: 8.10
misoprostol : 6.24

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