Eicosanoids & Vascular Pharmacology

Human vascular tissue research
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Host laboratory for BA, Master and PhD Thesis, contact: xnorel@hotmail.com,  INSERM U1148, Laboratory for Vascular Translational Science (LVTS). CHU X. Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France. Access, map. Tel: 33 1 40 25 75 29, Fax: 33 1 40 25 86 02.
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Last update: 14/09/15


Eicosanoids are metabolites of arachidonic acid derived from the action of the cyclooxygenase (cyclooxygenase pathway) or lypoxygenase enzymatic pathways. These metabolites may control the smooth muscle tone, the cell proliferation and migration in human vascular bed. Most of our present studies concern the 8 different prostanoid receptor subtypes (DP, EP1-4, FP, IP, TP) activated by prostaglandins and/or thromboxane and the enzymatic activities ( COX-1, COX-2, mPGES...) involved in the cyclooxygenase pathway. The roles of prostanoids in the human vascular wall are investigated in physiological and pathophysiological conditions (pulmonary hypertension, systemic hypertension, varicosity, atherosclerosis, aneurysm, preeclamsia).

GREMI (French Inflammation Society meeting



Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling. Eur. J. Pharmacol. 2015

Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the pre-contractile agents. Prostaglandins Other Lipid Mediat. 2015.

Decreased PGE2 Content Reduces MMP-1 Activity and Consequently Increases Collagen Density in Human Varicose Vein. 
PLoS One. 2014, Feb 5;9(2)
The role of prostaglandin E2 in human vascular inflammation. Prostaglandins Leukot Essent Fatty Acids. 2013 Aug; 89(2-3):55-63.

The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts. Am J Respir Crit Care Med. 2013 Apr 1;187(7):703-14. doi: 10.1164/rccm.201208-1361OC.

Absence of inflammatory conditions in human varicose saphenous veins. Inflamm Res. 2013 Mar;62(3):299-308. doi: 10.1007/s00011-012-0578-8.