Eicosanoids & Vascular Pharmacology

Introduction

Eicosanoids are metabolites of arachidonic acid derived from the action of the cyclooxygenase (cyclooxygenase pathway) or lypoxygenase enzymatic pathways. These metabolites may control the smooth muscle tone, the cell proliferation and migration in human vascular bed. Most of our present studies concern the 8 different prostanoid receptor subtypes (DP, EP1-4, FP, IP, TP) activated by prostaglandins and/or thromboxane and the enzymatic activities ( COX-1, COX-2, mPGES...) involved in the cyclooxygenase pathway. The roles of prostanoids in the human vascular wall are investigated in physiological and pathophysiological conditions (pulmonary hypertension, systemic hypertension, varicosity, atherosclerosis, aneurysm, preeclamsia).

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LAST PUBLICATIONS of the RESEARCH GROUP:

Reviews

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 2017 Dec;174 Suppl 1:S1-S16. doi: 10.1111/bph.13882. PubMed PMID: 29055037; PubMed Central PMCID: PMC5650665.

Prostanoids in the pathophysiology of human coronary artery. Prostaglandins Other Lipid Mediat. PDF 2017 Mar 24. pii: S1098-8823(16)30160-5. doi: 10.1016/j.prostaglandins.2017.03.003. [Epub ahead of print] Review. PubMed PMID: 28347710.

Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling. Eur J Pharmacol. PDF 2015 Nov 5;766:16-24. doi: 10.1016/j.ejphar.2015.09.012. Epub 2015 Sep 28. Review. PubMed PMID: 26424111.

The Concise Guide to PHARMACOLOGY 2015/16, Overview: Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347. PubMed PMID: 26650438; PubMed Central PMCID: PMC4718217. PDF GPCR.

The role of prostaglandin E2 in human vascular inflammation. Prostaglandins Leukot Essent Fatty Acids. PDF 2013 Aug;89(2-3):55-63. doi: 10.1016/j.plefa.2013.04.004. Epub 2013 Jun 4. Review. PubMed PMID: 23756023.

Prostanoid receptors in the human vascular wall. ScientificWorldJournal. PDF 2007 Sep 1;7:1359-74. Review. PubMed PMID: 17767355.

Data publications

Inflammation increases MMP levels via PGE(2) in human vascular wall and plasma of obese women. PDF Int J Obes (Lond). 2018 Oct 22. doi: 10.1038/s41366-018-0235-6. [Epub ahead of print] PubMed PMID: 30349011.

Neutrophils recruited by leukotriene B4 induce features of plaque destabilization during endotoxemia. Cardiovasc Res. 2018 May 24. doi: 10.1093/cvr/cvy130. [Epub ahead of print] PubMed PMID: 29800147.

I nhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI(2) : a safer alternative to COX-2 inhibition. Br J Pharmacol. 2017 Nov;174(22):4087-4098. doi: 10.1111/bph.13939. Epub 2017 Aug 11. PubMed PMID: 28675448.

Decreased vasorelaxation induced by iloprost during acute inflammation in human internal mammary artery. Eur J Pharmacol. 2017 Mar 31. pii: S0014-2999(17)30229-7. doi: 10.1016/j.ejphar.2017.03.060. [Epub ahead of print] PubMed PMID: 28373136.

Reverse Regulatory Pathway (H2S / PGE2 / MMP) in Human Aortic Aneurysm and Saphenous Vein Varicosity. PLoS One. PDF 2016 Jun 30;11(6):e0158421. doi: 10.1371/journal.pone.0158421. eCollection 2016. PubMed PMID: 27362269.

Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents. Prostaglandins Other Lipid Mediat. PDF 2015 Sep;121(Pt A):46-52. doi: 10.1016/j.prostaglandins.2015.09.002. Epub 2015 Sep 8. PubMed PMID: 26362969.

Decreased PGE2 content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. PLoS One. 2014 Feb 5;9(2):e88021. doi: 10.1371/journal.pone.0088021. eCollection PDF 2014. PubMed PMID: 24505358; PubMed
Central PMCID: PMC3914898.