INTRODUCTION:
Eicosanoids are metabolites of arachidonic acid derived from the action of the cyclooxygenase (cyclooxygenase pathway) or lypoxygenase enzymatic pathways. These metabolites may control the smooth muscle tone, the cell proliferation and migration in human vascular bed.

Most of our present studies concern the 8 different prostanoid receptor subtypes (DP, EP1-4, FP, IP, TP) activated by prostaglandins and/or thromboxane and the enzymatic activities ( COX-1, COX-2, mPGES...) involved in the cyclooxygenase pathway. The roles of prostanoids in the human vascular wall are investigated in physiological and pathophysiological (hypertension, atherosclerosis, aneurysm) conditions.

 

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We co-organize the "3rd European Workshop on Lipid Mediators"
Website: Program, abstract submission, information and registration

 

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Dr Nabil Foudi presented a part of his thesis work performed in our group at the 9th World Congress on Inflammation (Tokyo, 6-10 July, 2009) and got the 3rd prize at the Young Investigator's Award Session

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LAST PUBLICATIONS:

Selective COX-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation. Cardiovasc Res: 2009.

Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP(4) receptor subtype. Br J Pharmacol: 2008, 154(8), 1631-9

A new mRNA splice variant coding for the human EP(3-I) receptor isoform. PLEFA: 2007, 77(3-4), 195-201

Eicosanoid Receptors and Inflammation. TheScientificWorldJOURNAL: 2007, 7, 1359-74

 

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