Eicosanoids & Vascular Pharmacology

Human vascular tissue research
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Host laboratory for BA, Master and PhD Thesis, contact: xnorel@hotmail.com,  INSERM U1148, Laboratory for Vascular Translational Science (LVTS). CHU X. Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France. Access, map. Tel: 33 1 40 25 75 29, Fax: 33 1 40 25 86 02.
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Last update: 17/04/17

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Prostanoid receptors
in human pulmonary vessels
Prostanoid receptors
in human vessels
Cholinergic control
in human pulmonary vessels
Leukotriene receptors
in human pulmonary vessels
Laboratory & Links
Publications


Introduction

Eicosanoids are metabolites of arachidonic acid derived from the action of the cyclooxygenase (cyclooxygenase pathway) or lypoxygenase enzymatic pathways. These metabolites may control the smooth muscle tone, the cell proliferation and migration in human vascular bed. Most of our present studies concern the 8 different prostanoid receptor subtypes (DP, EP1-4, FP, IP, TP) activated by prostaglandins and/or thromboxane and the enzymatic activities ( COX-1, COX-2, mPGES...) involved in the cyclooxygenase pathway. The roles of prostanoids in the human vascular wall are investigated in physiological and pathophysiological conditions (pulmonary hypertension, systemic hypertension, varicosity, atherosclerosis, aneurysm, preeclamsia).

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LAST PUBLICATIONS of the RESEARCH GROUP:

Reviews

Prostanoids in the pathophysiology of human coronary artery. Prostaglandins Other Lipid Mediat. PDF 2017 Mar 24. pii: S1098-8823(16)30160-5. doi: 10.1016/j.prostaglandins.2017.03.003. [Epub ahead of print] Review. PubMed PMID: 28347710.

Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling. Eur J Pharmacol. PDF 2015 Nov 5;766:16-24. doi: 10.1016/j.ejphar.2015.09.012. Epub 2015 Sep 28. Review. PubMed PMID: 26424111.

The Concise Guide to PHARMACOLOGY 2015/16, Overview: Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347. PubMed PMID: 26650438; PubMed Central PMCID: PMC4718217. PDF GPCR.

The role of prostaglandin E2 in human vascular inflammation. Prostaglandins Leukot Essent Fatty Acids. PDF 2013 Aug;89(2-3):55-63. doi: 10.1016/j.plefa.2013.04.004. Epub 2013 Jun 4. Review. PubMed PMID: 23756023.

Prostanoid receptors in the human vascular wall. ScientificWorldJournal. PDF 2007 Sep 1;7:1359-74. Review. PubMed PMID: 17767355.

Data publications 

Decreased vasorelaxation induced by iloprost during acute inflammation in human internal mammary artery. Eur J Pharmacol. 2017
Mar 31. pii: S0014-2999(17)30229-7. doi: 10.1016/j.ejphar.2017.03.060. [Epub ahead of print] PubMed PMID: 28373136.

Reverse Regulatory Pathway (H2S / PGE2 / MMP) in Human Aortic Aneurysm and Saphenous Vein Varicosity. PLoS One. PDF 2016 Jun 30;11(6):e0158421. doi: 10.1371/journal.pone.0158421. eCollection 2016. PubMed PMID: 27362269.

Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the precontractile agents. Prostaglandins Other Lipid Mediat. PDF 2015 Sep;121(Pt A):46-52. doi: 10.1016/j.prostaglandins.2015.09.002. Epub 2015 Sep 8. PubMed PMID: 26362969.

Decreased PGE2 content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. PLoS One. 2014 Feb 5;9(2):e88021. doi: 10.1371/journal.pone.0088021. eCollection PDF 2014. PubMed PMID: 24505358; PubMed
Central PMCID: PMC3914898.