Eicosanoids & Vascular Pharmacology

Human vascular tissue research
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Host laboratory for BA, Master and PhD Thesis, contact: xnorel@hotmail.com,  INSERM U1148, Laboratory for Vascular Translational Science (LVTS). CHU X. Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France. Access, map. Tel: 33 1 40 25 75 29, Fax: 33 1 40 25 86 02.
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Last update: 2/07/16



Introduction

Eicosanoids are metabolites of arachidonic acid derived from the action of the cyclooxygenase (cyclooxygenase pathway) or lypoxygenase enzymatic pathways. These metabolites may control the smooth muscle tone, the cell proliferation and migration in human vascular bed. Most of our present studies concern the 8 different prostanoid receptor subtypes (DP, EP1-4, FP, IP, TP) activated by prostaglandins and/or thromboxane and the enzymatic activities ( COX-1, COX-2, mPGES...) involved in the cyclooxygenase pathway. The roles of prostanoids in the human vascular wall are investigated in physiological and pathophysiological conditions (pulmonary hypertension, systemic hypertension, varicosity, atherosclerosis, aneurysm, preeclamsia).

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LAST PUBLICATIONS of the RESEARCH GROUP:

Reverse Regulatory Pathway (H2S / PGE2 / MMP) in Human Aortic Aneurysm and Saphenous Vein Varicosity. PLoS One. 2016 Jun 30;11(6):e0158421. doi: 10.1371/journal.pone.0158421. eCollection 2016. PubMed PMID: 27362269.

Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling. Eur J Pharmacol. 2015 Nov 5;766:16-24. doi: 10.1016/j.ejphar.2015.09.012. Epub 2015 Sep 28. Review. PubMed PMID: 26424111.

The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 2015 Dec;172(24):5729-43. doi: 10.1111/bph.13347. PubMed PMID: 26650438; PubMed Central PMCID: PMC4718217.

Ex vivo relaxations of pulmonary arteries induced by prostacyclin mimetics are highly dependent of the pre-contractile agents. Prostaglandins Other Lipid Mediat. 2015.


Decreased PGE2 Content Reduces MMP-1 Activity and Consequently Increases Collagen Density in Human Varicose Vein. 
PLoS One. 2014, Feb 5;9(2).