Eicosanoids & Vascular Pharmacology

 

 
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Host laboratory for BA, Master and PhD Thesis, contact: xnorel@hotmail.com,  INSERM U698, Haemostasis, Bio-engineering and  Cardiovascular Remodeling. CHU X. Bichat, 46, rue Henri Huchard, 75877 Paris Cedex 18, France. Access, map. Tel: 33 1 40 25 75 29, Fax: 33 1 40 25 86 02.

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Human vascular tissue research

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X. Norel (PhD) & N. Foudi (PhD)
© 2009-2011 Eicosanoids & Vasc. Pharmacol. about the websit

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Prostanoid receptors
in human pulmonary vessels
Prostanoid receptors
in human vessels
Cholinergic control
in human pulmonary vessels
Leukotriene receptors
in human pulmonary vessels
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Last update : 28/11/12
 
INTRODUCTION:
Eicosanoids are metabolites of arachidonic acid derived from the action of the cyclooxygenase (cyclooxygenase pathway) or lypoxygenase enzymatic pathways. These metabolites may control the smooth muscle tone, the cell proliferation and migration in human vascular bed. Most of our present studies concern the 8 different prostanoid receptor subtypes (DP, EP1-4, FP, IP, TP) activated by prostaglandins and/or thromboxane and the enzymatic activities ( COX-1, COX-2, mPGES...) involved in the cyclooxygenase pathway. The roles of prostanoids in the human vascular wall are investigated in physiological and pathophysiological conditions (pulmonary hypertension, systemic hypertension, varicosity, atherosclerosis, aneurysm, preeclamsia).


"4th European Workshop on Lipid Mediators"
Photos of the Workshop
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